해당 논문에 의하면, COVID-19에 대한 Timbetasin 예측효과로써 섬유소 용해를 증가시켜 COVID-19에 관련된 응고 장애를 줄일 수 있는 것으로 언급하였습니다 (TB4 is down-regulated by Covid 130 fold).
지트리비앤트는 이 논문과 관련하여 더 자세한 정보와 과학적 논의를 위하여 Daniel Jacobson박사와 접촉을 시작하였습니다. Daniel Jacobson박사 테네시주립대 교수로서 미국 내 Computational Systems Biology 분야 최고 권위자 중 한 사람으로서 이 논문을 주도한 과학자 입니다.
– 발표논문 중 TB4와 관련 된 주요 내용입니다.
Although not the focus of the present study, coagulopathy is commonly reported in cases of COVID- 19 (The Lancet Haematology, 2020), and there are suggestions in the literature of links between RAS and coagulopathy. The Ang1-9 peptide that is increased in COVID-19 BAL stimulates hrombosis by inhibiting fibrinolysis (Mogielnicki et al., 2014). In addition to BK, ACE also degrades the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), which is produced from thy- mosin beta-4 (TMSB4X, -130 fold) (Kanasaki, 2020). Increased fibrinolysis could therefore be achieved by increasing ACE, or by administering thymosin beta-4, which is currently in clinical trials for the treatment of cardiovascular disorders (Timbetasin). If TMSB4X is, in fact, protective, it could explain the lower incidence of COVID-19 induced mortality in women (Jin et al., 2020) because it is found on the X chromosome and escapes X-inactivation. Women therefore would have twice the lev-els of this protein than men, which is supported by our BAL analysis (-207 fold in males, -131 fold in females).
The research, entitled A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm, was published in eLife 2020;9:e59177 DOI: 10.7554/eLife.59177. The research was conducted by Michael R Garvin1, Christiane Alvarez1, J Izaak Miller1, Erica T Prates1, Angelica M Walker1,2, B Kirtley Amos3, Alan E Mast4, Amy Justice5, Bruce Aronow6,7, Daniel Jacobson1,2,8*
1Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States; 2University of Tennessee Knoxville, The Bredesen Center for Interdisciplinary Research and Graduate Education, Knoxville, United States; 3University of Kentucky, Department of Horticulture, Lexington, United States; 4Versiti Blood Research Institute, Medical College of Wisconsin, Milwaukee, United States; 5VA Connecticut Healthcare/General Internal Medicine, Yale University School of Medicine, West Haven, United States; 6University of Cincinnati, Cincinnati, United States; 7Biomedical Informatics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, United States; 8University of Tennessee Knoxville, Department of Psychology, Austin Peay Building, Knoxville, United States